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Heroin Addiction and Related Clinical Problems: 2020, 22, N1 (pages: 7 - 8)
Gohari J., and Riaz U.
Summary: Lower doses of mood stabilizers may be necessary in patients receiving Methadone, especially when considering the metabolic syndrome and prolongation of QT interval which both Methadone and some psychoactive medications can cause. Research has shown that Methadone is a Āµ-opioid receptor agonist, as well as a serotonin and noradrenaline uptake inhibitor and NMDA receptor antagonist. Moreover, Methadone has the most evidence of efficacy in comorbid BD and opioid use disorder. We present here a case of a pregnant individual with a history of substance use disorder, BD-II and ADHD.
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