HEROIN ADDICTION AND
RELATED CLINICAL PROBLEMS

The official journal of
EUROPAD - European Opiate Addiction Treatment Association
WFTOD - World Federation for the Treatment of Opioid Dependence

Editor: Icro Maremmani, MD - Pisa, Italy, EU
Associate Editors:	Thomas Clausen, MD - Oslo, Norway Pier Paolo Pani, MD - Cagliari, Italy, EU Marta Torrens, MD - Barcelona, Spain, EU
Statistical Editor:	Mario Miccoli, PhD - Pisa, Italy, EU

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Heroin Addiction and Related Clinical Problems: 2014, 16, 2 (pages: 31 - 36)

Buprenorphine/ Buprenorphine-naloxone treatment in opioid dependence and risk of peripheral oedema: Mini-review

Soyka M.

Summary: Safety issues are of great concern in opioid maintenance therapy. Recently the European medicines agency raised the issue of peripheral oedema in buprenorphine treated patients. A medline search for reports on peripheral oedema in buprenorphine was performed and relevant websites were screened. To date few cases have been reported but the side effect is listed as common. Histamine release is associated with opioid use but not shown for buprenorphine in the skin. Possible implications are discussed.

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HEROIN ADDICTION AND RELATED CLINICAL PROBLEMS

The official journal of EUROPAD - European Opiate Addiction Treatment Association WFTOD - World Federation for the Treatment of Opioid Dependence

Editor: Icro Maremmani, MD - Pisa, Italy, EU

Associate Editors:

Thomas Clausen, MD - Oslo, Norway Pier Paolo Pani, MD - Cagliari, Italy, EU Marta Torrens, MD - Barcelona, Spain, EU

Statistical Editor:

Mario Miccoli, PhD - Pisa, Italy, EU