HARCP

HEROIN ADDICTION AND
RELATED CLINICAL PROBLEMS

The official journal of
EUROPAD - European Opiate Addiction Treatment Association
WFTOD - World Federation for the Treatment of Opioid Dependence
Editor: Icro Maremmani, MD - Pisa, Italy, EU
Associate Editors:
Thomas Clausen, MD - Oslo, Norway
Pier Paolo Pani, MD - Cagliari, Italy, EU
Marta Torrens, MD - Barcelona, Spain, EU
Statistical Editor:
Mario Miccoli, PhD - Pisa, Italy, EU

HARCP Archives

Browse by article Browse by volume    

Heroin Addiction and Related Clinical Problems: 2005, 07, 4 (pages: 49 - 58)

Methadone serum concentration and its relationship to methadone dose revisited

Okruhlica L., Valentova J., Devinsky F., Formakova S., Klempova D.

Summary: The study sample included 64 patients, who were divided into two subgroups on the basis of their daily methadone dose: ´Group 1´: 29 patients with doses up to 80 mg; ´Group 2´: 35 patients with doses above 80 mg. The overall correlation in the whole group was: r = 0.570. A strong correlation was found between dose and serum concentration in ‘Group 1': r = 0.799. Non-significant correlation close to zero was found in ‘Group 2'. Our findings suggest that the linear relationship between methadone dose and its serum concentration in lower doses cannot be extrapolated to higher doses.

 

AU-CNS Associazione per l’Utilizzo delle Conoscenze Neuroscientifiche a fini Sociali
Association for the Application of Neuroscientific Knowledge to Social Aims
Via XX Settembre, 83 – 55045 PIETRASANTA (Lucca) - Italy
P. IVA 01681650469 – Codice Fiscale 94002580465 Reserved Area
Tel/Phone: 0584 - 790073 - Email: info@heroinaddictionrelatedclinicalproblems.org		 Start of page